209 research outputs found
Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production
IL-2 is a pleiotropic cytokine that promotes the differentiation of Th cell subsets, including Th1, Th2, and Th9 cells, but it impairs the development of Th17 and T follicular helper cells. Although IL-2 is produced by all polarized Th subsets to some level, how it impacts cytokine production when effector T cells are restimulated is unknown. We show in this article that Golgi transport inhibitors (GTIs) blocked IL-9 production. Mechanistically, GTIs blocked secretion of IL-2 that normally feeds back in a paracrine manner to promote STAT5 activation and IL-9 production. IL-2 feedback had no effect on Th1- or Th17-signature cytokine production, but it promoted Th2- and Th9-associated cytokine expression. These data suggest that the use of GTIs results in an underestimation of the presence of type 2 cytokine-secreting cells and highlight IL-2 as a critical component in optimal cytokine production by Th2 and Th9 cells in vitro and in vivo
Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation
Paraproteinemia can be complicated by necrobiotic xanthogranuloma. Therapeutic options for this progressive disease are limited, and there is no agreement on a single best strategy. We report the case of a patient with a massive periorbital infiltration narrowing the palpebral fissure and blinding the patient. Conventional myeloma therapy had only limited benefit in our patient. However, he was successfully treated with high-dose chemotherapy followed by autologous stem cell transplantation, rendering the patient free of symptoms. This is the first report of autologous stem cell transplantation in a patient with necrobiotic xanthogranulom
How well can superconducting nanowire single-photon detectors resolve photon number?
We apply principal component analysis (PCA) to a set of electrical output
signals from a commercially available superconducting nanowire single-photon
detector (SNSPD) to investigate their photon-number-resolving capability. We
find that the rising edge as well as the amplitude of the electrical signal
have the most dependence on photon number. Accurately measuring the rising edge
while simultaneously measuring the voltage of the pulse amplitude maximizes the
photon-number resolution of SNSPDs. Using an optimal basis of principle
components, we show unambiguous discrimination between one- and two-photon
events, as well as partial resolution up to five photons. This expands the
use-case of SNSPDs to photon-counting experiments, without the need of detector
multiplexing architectures.Comment: 7 pages, 5 figure
Continuum Halos in Nearby Galaxies -- an EVLA Survey (CHANG-ES) -- II: First Results on NGC 4631
We present the first results from the CHANG-ES survey, a new survey of 35
edge-on galaxies to search for both in-disk as well as extra-planar radio
continuum emission. The motivation and science case for the survey are
presented in a companion paper (Paper I). In this paper (Paper II), we outline
the observations and data reduction steps required for wide-band calibration
and mapping of EVLA data, including polarization, based on C-array test
observations of NGC 4631.
With modest on-source observing times (30 minutes at 1.5 GHz and 75 minutes
at 6 GHz for the test data) we have achieved best rms noise levels of 22 and
3.5 Jy beam at 1.5 GHz and 6 GHz, respectively. New disk-halo
features have been detected, among them two at 1.5 GHz that appear as loops in
projection. We present the first 1.5 GHz spectral index map of NGC 4631 to be
formed from a single wide-band observation in a single array configuration.
This map represents tangent slopes to the intensities within the band centered
at 1.5 GHz, rather than fits across widely separated frequencies as has been
done in the past and is also the highest spatial resolution spectral index map
yet presented for this galaxy. The average spectral index in the disk is
indicating that the emission is
largely non-thermal, but a small global thermal contribution is sufficient to
explain a positive curvature term in the spectral index over the band. Two
specific star forming regions have spectral indices that are consistent with
thermal emission. Polarization results (uncorrected for internal Faraday
rotation) are consistent with previous observations and also reveal some new
features. On broad scales, we find strong support for the notion that magnetic
fields constrain the X-ray emitting hot gas.Comment: Accepted to the Astronomical Journal, Version 2 changes: Added
acknowledgement to NRA
Nonlocal pair correlations in Lieb-Liniger gases -- a unified non-perturbative approach from weak degeneracy to high temperatures
We present analytical results for the nonlocal pair correlations in one-dimensional bosonic systems with repulsive contact interactions that are uniformly valid from the classical regime of high temperatures down to weak quantum degeneracy entering the regime of ultralow temperatures. By using the information contained in the short-time approximations of the full many-body propagator we derive results that are non-perturbative in the interaction parameter while covering a wide range of temperatures and densities. For the case of three particles we give a simple formula for arbitrary couplings that is exact in the dilute limit while remaining valid up to the regime where the thermal de Broglie wavelength λT is of the order of the characteristic length L of the system. We then show how to use this result to find analytical expressions for the nonlocal correlations for arbitrary but fixed particle numbers N including finite size corrections. Neglecting the latter in the thermodynamic limit provides an expansion in the quantum degeneracy parameter NλT/L. We compare our analytical results with numerical Bethe ansatz calculations finding excellent agreement
Semiclassics in a system without classical limit: The few-body spectrum of two interacting bosons in one dimension
xWe present a semiclassical study of the spectrum of a few-body system consisting of two short-range interacting bosonic particles in one dimension, a particular case of a general class of integrable many-body systems where the energy spectrum is given by the solution of algebraic transcendental equations. By an exact mapping between delta-potentials and boundary conditions on the few-bodywave functions, we are able to extend previous semiclassical results for single-particle systems with mixed boundary conditions to the two-body problem. The semiclassical approach allows us to derive explicit analytical results for the smooth part of the two-body density of states that are in excellent agreement with numerical calculations. It further enables us to include the effect of bound states in the attractive case. Remarkably, for the particular case of two particles in one dimension, the discrete energy levels obtained through a requantization condition of the smooth density of states are essentially in perfect agreement with the exact ones
Continuum Halos in Nearby Galaxies -- an EVLA Survey (CHANG-ES) -- I: Introduction to the Survey
We introduce a new survey to map the radio continuum halos of a sample of 35
edge-on spiral galaxies at 1.5 GHz and 6 GHz in all polarization products. The
survey is exploiting the new wide bandwidth capabilities of the Karl G. Jansky
Very Large Array (i.e. the Expanded Very Large Array, or EVLA) in a variety of
array configurations (B, C, and D) in order to compile the most comprehensive
data set yet obtained for the study of radio halo properties. This is the first
survey of radio halos to include all polarization products.
In this first paper, we outline the scientific motivation of the survey, the
specific science goals, and the expected improvements in noise levels and
spatial coverage from the survey. Our goals include investigating the physical
conditions and origin of halos, characterizing cosmic ray transport and wind
speed, measuring Faraday rotation and mapping the magnetic field, probing the
in-disk and extraplanar far-infrared - radio continuum relation, and
reconciling non-thermal radio emission with high-energy gamma-ray models. The
sample size allows us to search for correlations between radio halos and other
properties, including environment, star formation rate, and the presence of
AGNs. In a companion paper (Paper II) we outline the data reduction steps and
present the first results of the survey for the galaxy, NGC 4631.Comment: 17 pages, 1 figure, accepted to the Astronomical Journal, Version 2
changes: added acknowledgement to NRA
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